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Recommendations for Follow Up After OneTest™

Lung Cancer

Elevated Biomarkers

CYFRA 21-1

CA 125


  • Persistent cough
  • Coughing up blood
  • Chest pain that worsens with deep breathing, coughing, or laughing
  • Hoarseness
  • Shortness of breath
  • Wheezing
  • Unexplained weight loss
  • Fatigue
  • Recurrent respiratory infections


  • Abnormal lung sounds (crackles or wheezes) heard through a stethoscope
  • Clubbing of the fingers or toes
  • Enlarged lymph nodes in the neck or above the collarbone

Risk Factors

  • Smoking: the most significant risk factor for lung cancer. The risk increases with the number of cigarettes smoked and the duration of smoking.
  • Secondhand smoke exposure
  • Radon exposure
  • Asbestos exposure
  • Air pollution
  • Family history of lung cancer
  • Personal history of lung disease (COPD, tuberculosis)
  • Exposure to certain chemicals (arsenic, chromium, nickel)
  • Radiation therapy to the chest

Other Screening Tools:

  • Low-dose CT scan: Recommended annually for individuals aged 50 to 80 years who have a 20 pack-year smoking history and currently smoke or have quit within the past 15 years.
  • Chest X-ray: Not recommended for lung cancer screening due to its low sensitivity and specificity.

Next Exam(s) To Do

  • Low-dose CT scan: If OneTest indicates elevated predictive risk for lung cancer, a low-dose CT scan would be performed for further evaluation. This imaging test can detect lung nodules or masses that may be indicative of lung cancer.
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