Endometrial Cancer
Elevated Biomarkers:
- CA 125
- HE 4
Symptoms:
- Abnormal vaginal bleeding, such as bleeding between periods, after menopause, or after sex.
- Pelvic pain or discomfort
- Pain during intercourse
- Unexplained weight loss
- Fatigue
Signs:
- Enlarged uterus
- Enlarged lymph nodes in the pelvis
Risk Factors
- Age: The risk of endometrial cancer increases with age, with most cases occurring in women aged 50 and older.
- Obesity: Being overweight or obese increases the risk, especially if the excess weight is carried around the abdomen.
- Hormone Replacement Therapy (HRT): Long-term use of estrogen without progesterone increases the risk.
- Diabetes: Having diabetes increases the risk, especially if it is poorly controlled.
- Polycystic Ovary Syndrome (PCOS): Having PCOS increases the risk.
- Family History: Having a first-degree relative (parent, sibling, or child) with endometrial cancer increases the risk.
- Previous cancer treatment: Previous treatment with tamoxifen, a drug used to treat breast cancer, increases the risk
- Lynch syndrome: An inherited genetic condition that increases the risk of several types of cancer, including endometrial cancer
Other Screening Tools:
- Pelvic ultrasound: Recommended for individuals with risk factors for endometrial cancer or symptoms suggestive of endometrial cancer.
- Endometrial biopsy: Recommended if abnormalities are detected during a pelvic ultrasound or if endometrial cancer is suspected.
- Imaging tests (CT scan, MRI): Recommended for individuals with risk factors for endometrial cancer or symptoms suggestive of endometrial cancer.
Next Exam(s) To Do
- Ultrasound: If OneTest Indicates elevated predictive risk for endometrial cancer, an abdominal or transvaginal ultrasound would be performed for further evaluation.
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