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Recommendations for Follow Up After OneTest™

Breast Cancer

Elevated Biomarkers

CA 15-3


  • Lump or mass in the breast or underarm area
  • Changes in breast size, shape, or appearance
  • Changes in the skin over the breast, such as dimpling or puckering
  • Nipple changes, such as inversion, discharge, or scaling
  • Redness or swelling of the breast or nipple
  • Breast pain or tenderness


  • Visible or palpable lump or mass in the breast or underarm area
  • Changes in breast size, shape, or appearance

Risk Factors

  • Gender: Breast cancer is more common in women, but it can also occur in men.
  • Age: The risk of breast cancer increases with age, with most cases occurring in women over 50.
  • Family history: Having a first-degree relative (mother, sister, or daughter) with breast cancer increases the risk
  • Personal history: A previous diagnosis of breast cancer or certain benign breast conditions increases the risk
  • Genetic mutation: Inherited mutation in the BRCA1 and BRCA2 genes increase the risk
  • Hormone replacement therapy (HRT): Long-term use of HRT containing estrogen and progesterone increases the risk
  • Reproductive factors: Early menstruation, late menopause, and never having children or having the first child after age 30 increase the risk
  • Alcohol consumption: Regular alcohol consumption increases the risk
  • Obesity: Being overweight or obese increases the risk, especially after menopause.

Other Screening Tools:

  • Mammography: Recommended every 1-2 years for women aged 40 or older. It is the gold standard for breast cancer screening.
  • Breast MRI: Recommended for women with a high risk of breast cancer, such as those with a strong family history or BRCA gene mutations.
  • Breast Ultrasound: Used as a supplemental screening tool for women with dense breast tissue or for further evaluation of abnormalities detected on mammography.

Next Exam(s) To Do

  • Mammography or ultrasonography: If OneTest indicates elevated predictive risk for breast cancer, a mammogram or ultrasonography (depends on age) would be performed for further evaluation. Mammography/ultrasonography can detect breast abnormalities, such as masses or calcifications, that may be indictive of breast cancer.
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